Antibiotic depot system with radiofrequency controlled drug release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43924684" target="_blank" >RIV/60461373:22310/22:43924684 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/22:43924684
Result on the web
<a href="https://doi.org/10.1016/j.colsurfb.2022.112618" target="_blank" >https://doi.org/10.1016/j.colsurfb.2022.112618</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfb.2022.112618" target="_blank" >10.1016/j.colsurfb.2022.112618</a>
Alternative languages
Result language
angličtina
Original language name
Antibiotic depot system with radiofrequency controlled drug release
Original language description
Drug depot systems have traditionally relied on the spontaneous dissolution and diffusion of drugs or prodrugs from a reservoir with constant exposure to the surrounding physiological fluids. While this is appropriate for clinical scenarios that require constant plasma concentration of the drug over time, there are also situations where multiple bursts of the drug at well-defined time intervals are preferred. This work presents a drug depot system that enables repeated on-demand release of antibiotics in precise doses, controlled by an external radiofrequency magnetic field. The remotely controlled depot system consists of composite microcapsules with a core-shell structure. The core contains micronized drug particles embedded in a low-melting hydrophobic matrix. The shell is formed by a hydrogel with immobilised magnetic nanoparticles that facilitate local heat dissipation after exposure to a radiofrequency magnetic field. When the melting point of the core material is locally exceeded, the embedded drug particles are mobilised and their surface is exposed to the external aqueous phase. It is shown that drug release can be controlled in an on/off manner by a chosen sequence and duration of radiofrequency pulses. The capacity of the depot system is shown to be significantly higher than that of purely diffusion-controlled systems containing a pre-dissolved drug. The functionality of the depot system is demonstrated in vitro for the specific case of norfloxacin acting on E. coli.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/GA18-14466S" target="_blank" >GA18-14466S: Intensification of reaction-diffusion processes by magnetic nanomixing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces B: Biointerfaces
ISSN
0927-7765
e-ISSN
1873-4367
Volume of the periodical
217
Issue of the periodical within the volume
112618
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
nestrankovano
UT code for WoS article
000818784400001
EID of the result in the Scopus database
—