Development of Smart Sensing Film with Nonbiofouling Properties for Potentiometric Detection of Local pH Changes Caused by Bacterial and Yeast Infections Around Orthopedic Implants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43925151" target="_blank" >RIV/60461373:22310/22:43925151 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/23:00568558 RIV/68407700:21220/23:00361293 RIV/00216208:11110/23:10451750 RIV/00064203:_____/23:10451750
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/admi.202201878" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/admi.202201878</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/admi.202201878" target="_blank" >10.1002/admi.202201878</a>
Alternative languages
Result language
angličtina
Original language name
Development of Smart Sensing Film with Nonbiofouling Properties for Potentiometric Detection of Local pH Changes Caused by Bacterial and Yeast Infections Around Orthopedic Implants
Original language description
The local peri-implant pH changes caused by sterile inflammation and bacterial and fungal infections are studied herein. Then, a sensing electrode based on polyaniline and poly(2-methyl-2-oxazoline) on a titanium alloy support is developed for potentiometric detection of peri-implant pH changes to enable early detection of the aforementioned pathologies. The infected endoprosthesis area is shown to have an average pH of 0.79 units lower than the aseptic sample. The pH measurements of the individual pathogenic bacteria or pathogenic yeast reveal that Escherichia coli decreased the pH by 1.24 units, Staphylococcus aureus decreased the pH by 1.33 units and the methicillin-resistant Staphylococcus aureus bacteria decreased the pH from 7.2 to 5.6 during 10 h, followed by a subsequent increase to 6.4. The results are statistically significant (α = 0.01). Pseudomonas aeruginosa is not shown to change pH levels. On the other hand, the pathogenic yeast has the lowest recorded pH, which decreases from 5.8 to 4.8. This difference in pH can be used to identify the nature of the infection. The developed electrodes have a pH response between pH 5 and 8, with a Nernstian slope of −59.6/pH. The developed electrode can contribute to the next generation of biosensors
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Materials Interfaces
ISSN
2196-7350
e-ISSN
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Volume of the periodical
2201878
Issue of the periodical within the volume
2201878
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000895528500001
EID of the result in the Scopus database
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