Mechanistic study of dissolution enhancement by interactive mixtures of chitosan with meloxicam as model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43925898" target="_blank" >RIV/60461373:22310/22:43925898 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/22:10451091
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0928098721003882?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928098721003882?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2021.106087" target="_blank" >10.1016/j.ejps.2021.106087</a>
Alternative languages
Result language
angličtina
Original language name
Mechanistic study of dissolution enhancement by interactive mixtures of chitosan with meloxicam as model
Original language description
To enhance dissolution rate of meloxicam (MX), a poorly soluble model drug, a natural polysaccharide excipient chitosan (CH) is employed in this work as a carrier to prepare binary interactive mixtures by either mixing or comilling techniques. The MX-CH mixtures of three different drug loads were characterized for morphological, granulometric, and thermal properties as well as drug crystallinity. The relative dissolution rate of MX was determined in phosphate buffer of pH 6.8 using the USP-4 apparatus; a significant increase in MX dissolution rate was observed for both mixed and co-milled mixtures comparing to the raw drug. Higher dissolution rate of MX was evidently connected to surface activation by mixing or milling, which was pronounced by the higher specific surface energy as detected by inverse gas chromatography. In addition to the particle size reduction, the carrier effect of the CH was confirmed for co-milling by linear regression between the MX maximum relative dissolution rate and the total surface area of the mixture (R-2 = 0.863). No MX amorphization or crystalline structure change were detected. The work of adhesion/cohesion ratio of 0.9 supports the existence of preferential adherence of MX to the coarse particles of CH to form stable interactive mixtures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmaceutical Sciences
ISSN
0928-0987
e-ISSN
1879-0720
Volume of the periodical
169
Issue of the periodical within the volume
106087
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
nestrankovano
UT code for WoS article
000804547300004
EID of the result in the Scopus database
2-s2.0-85120995366