Preparation of pH-sensitive surface based on mixed oxides of titanium and iridium for early detection of inflammation around the implant

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F23%3A43926150" target="_blank" >RIV/60461373:22310/23:43926150 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0254058423007344?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0254058423007344?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.matchemphys.2023.128026" target="_blank" >10.1016/j.matchemphys.2023.128026</a>

Result language
angličtina
Original language name
Preparation of pH-sensitive surface based on mixed oxides of titanium and iridium for early detection of inflammation around the implant
Original language description
The surface of an implant used during operation is a preferred site for the attachment of harmful microorganisms. These subsequently affect the surrounding tissue with their metabolic products, including the tissue´s pH. The possibility of sensing the pH around the implant could be a way of detecting the infection in the early stages. Transition metal oxides can be used for these applications. The most common alloys used for the manufacture of implants are titanium alloys which are characterized by a passive TiO2 surface layer that can be modified. In this work, the Ti-6Al 4V alloy whose surface was nanostructured was used. Iridium particles were subsequently deposited on the prepared surface by various methods to increase the sensitivity to pH change. The potentiostatic mode was chosen as the most suitable method of deposition. Energy dispersive analysis and X-ray photoelectron spectroscopy verified the success of iridium particle deposition. The electrochemical response was measured in a physiological saline solution and monitoring the open circuit potential change proved to be the most appropriate sensing method. After subsequent oxidation process, the prepared surface showed a sensitivity of 64 mV/pH at 37 °C.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20501 - Materials engineering

Project
<a href="/en/project/NU20-06-00424" target="_blank" >NU20-06-00424: Implantable sensors for early detection of infection and bacterial colonization</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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