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Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F23%3A43928402" target="_blank" >RIV/60461373:22310/23:43928402 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.tandfonline.com/doi/full/10.1080/14756366.2023.2270180" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14756366.2023.2270180</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/14756366.2023.2270180" target="_blank" >10.1080/14756366.2023.2270180</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold

  • Original language description

    A novel library of human carbonic anhydrase (hCA) inhibitors based on the 2-sulfanilamido[1,2,4]triazolo[1,5-a]pyrimidine skeleton modified at its 7-position was prepared by an efficient convergent procedure. These derivatives were evaluated in vitro for their inhibition properties against a representative panel of hCA isoforms (hCA I, II, IV, IX, and XII). The target tumour-associated isoforms hCA IX and XII were potently inhibited with K Is in the low nanomolar range of 5–96 nM and 4–72 nM, respectively. Compounds 1d, 1j, 1v, and 1x were the most potent hCA IX inhibitors with K Is of 5.1, 8.6, 4.7, and 5.1 nM, respectively. Along with derivatives 1d and 1j, compounds 1r and 1ab potently inhibited hCA XII isoform with K Is in a single-digit nanomolar range of 8.8, 5.4, 4.3, and 9.0 nM, respectively. Compounds 1e, 1m, and 1p exhibited the best selectivity against hCA IX and hCA XII isoforms over off-target hCA II, with selectivity indexes ranging from 5 to 14. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

  • ISSN

    1475-6366

  • e-ISSN

  • Volume of the periodical

    38

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    ZA - SOUTH AFRICA

  • Number of pages

    21

  • Pages from-to

    "not paged"

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85174627641