Solid-state vibrational circular dichroism: Methodology and application for amphetamine derivatives.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F24%3A43927389" target="_blank" >RIV/60461373:22310/24:43927389 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/24:43927389 RIV/60461373:22340/24:43927389 RIV/00023752:_____/24:43921217
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S138614252301171X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S138614252301171X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.saa.2023.123486" target="_blank" >10.1016/j.saa.2023.123486</a>
Alternative languages
Result language
angličtina
Original language name
Solid-state vibrational circular dichroism: Methodology and application for amphetamine derivatives.
Original language description
Amphetamine derivatives are considered most seized substances worldwide. In this study, solid-state vibrational circular dichroism (VCD) measurements of enantiomerically pure substances were performed for spectroscopic discrimination between (S)- and (R)-enantiomers. First, we have developed a universal experimental approach to obtain reliable and reproducible solid-state VCD spectra. First, the samples were prepared as pellets composed of mixtures of camphor as a model compound and a crystalline matrix powder. In order to obtain the best results without artifacts and with a maximum signal-to-noise ratio, the following experimental conditions were optimized: pellet thickness and diameter and sample rotation speed. The optimized parameters were then used for the analysis of amphetamine and its derivatives (methamphetamine and 3,4-methylendioxymethamphetamine). Our high-quality spectra and results suggest that solid-state VCD spectroscopy represents a cost-effective and easy-to-use method for the analysis of conformation changes and molecular packing in solid-state with potential applications in pharmaceutical and forensic practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
ISSN
1386-1425
e-ISSN
1873-3557
Volume of the periodical
305
Issue of the periodical within the volume
15 January 2024
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
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UT code for WoS article
001098955300001
EID of the result in the Scopus database
2-s2.0-85173490676