Tuning parameters of single quadrupole mass detector hyphenated to supercritical fluid chromatography for enantioseparation of synthetic cathinones
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F24%3A43929121" target="_blank" >RIV/60461373:22310/24:43929121 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/24:43929121 RIV/00023752:_____/24:43921371
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2772391724000264" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2772391724000264</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcoa.2024.100139" target="_blank" >10.1016/j.jcoa.2024.100139</a>
Alternative languages
Result language
angličtina
Original language name
Tuning parameters of single quadrupole mass detector hyphenated to supercritical fluid chromatography for enantioseparation of synthetic cathinones
Original language description
In our previous paper, we introduced a new method for the enantioseparation of cathinones on chiral zwitterion ion exchangers by SFC-ESI-MS with an inverse make-up solvent gradient. The inverse gradient enabled us to stabilize electrospray ionization while simultaneously increasing MS response. In this study, we fine-tuned our previously optimized SFC-ESI-MS method and compared its efficiency with that of the default ESI-MS method. To enhance analyte detection, we designed a complex series of experiments in which all combinations of the following three parameters were evaluated: cone voltage (5 to 27 V), probe temperature (250 to 550 °C) and capillary voltage for positive ionization (0.3 to 1.5 kV). After optimization, various ratios of the make-up solvent (methanol/water/formic acid) introduced before entering the ESI ion source were also tested. Despite this comprehensive testing regime, there were no significant differences between the results obtained for the tuned and default ESI-MS parameters. Similarly, the most suitable make-up solvent composition was the originally used ratio of 90/10/0.1 (v/v/v). These results reinforce the findings of our previous paper, in which we optimized the make-up solvent flow rate and showed its significant impact on ESI-MS response. © 2024 The Author(s)
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/VK01010212" target="_blank" >VK01010212: New psychoactive substances: forensic-toxicology research center</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chromatography Open
ISSN
2772-3917
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
květen 2024
Country of publishing house
IE - IRELAND
Number of pages
8
Pages from-to
100139
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85194061304