Copper–PLLA-Based Biopolymer Wrinkle Structures for Enhanced Antibacterial Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43932172" target="_blank" >RIV/60461373:22310/25:43932172 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22320/25:43932172 RIV/60461373:22330/25:43932172
Result on the web
<a href="https://www.mdpi.com/2073-4360/17/16/2173" target="_blank" >https://www.mdpi.com/2073-4360/17/16/2173</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/polym17162173" target="_blank" >10.3390/polym17162173</a>
Alternative languages
Result language
angličtina
Original language name
Copper–PLLA-Based Biopolymer Wrinkle Structures for Enhanced Antibacterial Activity
Original language description
The increasing prevalence of antibiotic-resistant bacteria has intensified the need for innovative antibacterial surfaces, particularly in biomedical applications. Traditional approaches often rely on chemical agents alone, which may lead to diminishing efficacy over time. To address this, we investigated the development of a novel antibacterial surface by combining the inherent antimicrobial properties of copper with an engineered surface topography on a biopolymer matrix. A copper–poly-L-lactic acid (Cu-PLLA) composite system was fabricated using sputtering deposition followed by controlled thermal treatment to induce wrinkle-like micro- and nanostructures on the surface. The surface morphology was characterized using scanning electron microscopy (SEM) and atomic force microscopy (AFM), confirming the formation of hierarchical wrinkle patterns. The chemical composition and distribution of copper were analyzed via energy-dispersive X-ray spectroscopy (EDS). Antibacterial performance was assessed against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus using standard colony count reduction assays. The Cu-PLLA wrinkled surfaces demonstrated significantly enhanced bactericidal activity compared with flat PLLA and copper-free controls, a finding attributed to a synergistic effect of mechanical membrane disruption and copper-mediated chemical toxicity. These findings suggest that biopolymer–metal hybrid surfaces with engineered topography offer a promising strategy for developing next-generation antibacterial materials suitable for biomedical and clinical use.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymers
ISSN
2073-4360
e-ISSN
2073-4360
Volume of the periodical
17
Issue of the periodical within the volume
16
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
2173
UT code for WoS article
001557497500001
EID of the result in the Scopus database
2-s2.0-105014323109