Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F01%3A00004298" target="_blank" >RIV/60461373:22330/01:00004298 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/01:00005906

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics

Original language description

The osa gene of Drosophila melanogaster encodes a nuclear protein that is a component of the Brahma chromatin-remodeling complex. Osa is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Inthese tissues, osa mutations have effects opposite to those caused by wingless (wg) mutations, suggesting that osa functions as an antagonist of wg signaling. Here we describe the cloning and characterization of mammalian orthologues of osa. Three evolutionarily conserved domains were identified in Osa family members: the N-terminal Bright domain and C-terminally located Osa homology domains 1 and 2. RNase protection analysis indicates a widespread expression of the Osa1 gene during mouse development, in adult tissues, and in cultured cell lines. The Osa1 gene was localized to mouse chromosome 4, within the region syntenic to chromosomal position 1p35-p36 of its human counterpart. We present evidence that the OSA1 product is localized i

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

<a href="/en/project/LN00A079" target="_blank" >LN00A079: Center of Integrated Genomics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genomics

ISSN

0888-7543

e-ISSN

—

Volume of the periodical

73

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

140-148

UT code for WoS article

—

EID of the result in the Scopus database

—