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Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F01%3A00004481" target="_blank" >RIV/60461373:22330/01:00004481 - isvavai.cz</a>

  • Alternative codes found

    RIV/60461373:22330/01:00006079

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors.

  • Original language description

    The secretion of aspartic proteases by Candida spp. was demonstrated to be one of the virulence determinants. Candida albicans is classified in the genus Candida as the major human pathogen. However, other species of this genus cause a candidiases. We designed and prepared an inhibitor containing phenylstatine isoster that was equipotent towards all four proteases within the range of 10-10 - 10-9 M. The HIV-1 protease inhibitors were also tested for the inhibition of four Saps.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LN00A079" target="_blank" >LN00A079: Center of Integrated Genomics</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2001

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Europian Journal of Biochemistry

  • ISSN

    0014-2956

  • e-ISSN

  • Volume of the periodical

    Neuveden

  • Issue of the periodical within the volume

    268

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    2669-2677

  • UT code for WoS article

  • EID of the result in the Scopus database