LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F03%3A00008358" target="_blank" >RIV/60461373:22330/03:00008358 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/03:23033107
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Original language description
Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Thus, LIME appears to be involved in regulation of T cell activation by coreceptors.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Medicine
ISSN
0022-1007
e-ISSN
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Volume of the periodical
2003
Issue of the periodical within the volume
198
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1453-62
UT code for WoS article
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EID of the result in the Scopus database
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