Homology Modelling and Molecular Dynamics Simulation of Beta-Galactosidase from Antarctic Bacterium Arthrobacter sp. C2-2 - sborník

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F03%3A00008977" target="_blank" >RIV/60461373:22330/03:00008977 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Homology Modelling and Molecular Dynamics Simulation of Beta-Galactosidase from Antarctic Bacterium Arthrobacter sp. C2-2 - sborník
Original language description
Enzymes from cold adapted organisms are gaining interest as catalysts in biotechnology. bGalactosidase from Antarctic bacterium Arthrobacter sp. C2 2 was used as a model enzyme to study the structural b asis of adaptation to function at low temperature. Since the experimental structure is not yet known we used methodology of homology modelling and molecular dynamics simulation. Model was built by the method of homology modelling by satisfaction of spatial restraints. bGalactosidase from E.coli (PDB identifier 1DP0) and human bglucuronidase (PDB identifier 1BHG) were used as templates. To evaluate and optimize the model, homology modelling procedure was followed by simulation of 1 ns molecular dynamics. Presented work describes results of moleculardynamics simulation and their implication for understanding of mechanism of adaptation . Predicted structure of the enzyme is compared with its mesophilic counterpart and roles of electrostatic and hydrophobic interactions in adaptation ar
Czech name
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Czech description
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Project
<a href="/en/project/GA204%2F02%2F0843" target="_blank" >GA204/02/0843: Complex cold adaptation study of enzymes on molecular level and their application in biotechnology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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