Molecular modelling study of free-energy landscape of oxytocin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F05%3A00016087" target="_blank" >RIV/60461373:22330/05:00016087 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Molecular modelling study of free-energy landscape of oxytocin
Original language description
Oxytocin plays an important role in the controlof a number of physiological processes, including milk ejectionin lactating mammals, uterine smooth muscle contraction atbirth and specific behavioural features. Oxytocin receptors(GPCR type) were identifiedin the myoepithelium ofmammary gland and in the myometrial layer of uterus.Affinity spectra analysis indicates two populations ofoxytocin-myometrial receptor complexes, with apparentdissociation constants ca. 2x10-9 and 5x10-8 mol/l. On theother hand, Atosiban, an antagonistically acting syntheticanalogue of oxytocin possesses only a single dissociationconstant for its interaction with oxytocin receptor. Moreover,biophysical and molecular modelling studies showed thatoxytocin is present in solution intwo different conformationsthat are in a dynamics equilibrium [1-4]. The idea ofinvolvement of conformational duality of oxytocin in theduality of dissociation constants was also proposed [4].Number of molecular modelling techniques for c
Czech name
Molecular modelling study of free-energy landscape of oxytocin
Czech description
Molecular modelling study of free-energy landscape of oxytocin
Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA204%2F02%2F0843" target="_blank" >GA204/02/0843: Complex cold adaptation study of enzymes on molecular level and their application in biotechnology</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of third international and twenty-eighth European peptide symposium
ISBN
965-90833-0-0
ISSN
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e-ISSN
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Number of pages
2
Pages from-to
766-767
Publisher name
Kenes International
Place of publication
Geneve
Event location
Praha
Event date
Sep 5, 2004
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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