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Molecular modelling study of free-energy landscape of oxytocin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F05%3A00016087" target="_blank" >RIV/60461373:22330/05:00016087 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Molecular modelling study of free-energy landscape of oxytocin

  • Original language description

    Oxytocin plays an important role in the controlof a number of physiological processes, including milk ejectionin lactating mammals, uterine smooth muscle contraction atbirth and specific behavioural features. Oxytocin receptors(GPCR type) were identifiedin the myoepithelium ofmammary gland and in the myometrial layer of uterus.Affinity spectra analysis indicates two populations ofoxytocin-myometrial receptor complexes, with apparentdissociation constants ca. 2x10-9 and 5x10-8 mol/l. On theother hand, Atosiban, an antagonistically acting syntheticanalogue of oxytocin possesses only a single dissociationconstant for its interaction with oxytocin receptor. Moreover,biophysical and molecular modelling studies showed thatoxytocin is present in solution intwo different conformationsthat are in a dynamics equilibrium [1-4]. The idea ofinvolvement of conformational duality of oxytocin in theduality of dissociation constants was also proposed [4].Number of molecular modelling techniques for c

  • Czech name

    Molecular modelling study of free-energy landscape of oxytocin

  • Czech description

    Molecular modelling study of free-energy landscape of oxytocin

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA204%2F02%2F0843" target="_blank" >GA204/02/0843: Complex cold adaptation study of enzymes on molecular level and their application in biotechnology</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Proceedings of third international and twenty-eighth European peptide symposium

  • ISBN

    965-90833-0-0

  • ISSN

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

    766-767

  • Publisher name

    Kenes International

  • Place of publication

    Geneve

  • Event location

    Praha

  • Event date

    Sep 5, 2004

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article