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Synthesis and Conformational Properties of Partially Alkylated Methylene-Bridged Resorc[4]arenes - Study of the "Flip-Flop" Inversion

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F06%3A00016508" target="_blank" >RIV/60461373:22330/06:00016508 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15310/06:00009828

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and Conformational Properties of Partially Alkylated Methylene-Bridged Resorc[4]arenes - Study of the "Flip-Flop" Inversion

  • Original language description

    The deprotection of resorc[4]arene octaisopropyl ether by boron trichloride been found to give a parent resorc[4]arene, as well as a mixture of partially alkylated derivatives. The conformational behaviour of the prepared alkyl ethers was studied with temperature-dependent 1H NMR spectroscopy and quantum chemical calculations. It was found that the compounds interconvert between two possible identical crown conformations (flip-flop inversion). The activation free energy values for this process, obtainedby NMR, strongly depends on the number of hydroxy groups in the molecule. The flip-flop inversion was not observed in the cases of fully deprotected compound and monoisopropyl resorc[4]arenes. Molecular modelling studies revealed that the flip-flop inversion proceeds via the consecutive rotation of two adjacent rings.

  • Czech name

    Syntéza a konformační vlastnosti parciálně alkylovaných resorc[4]arenů - studium flip-flop inverze

  • Czech description

    Reakcí oktaisopropyletheru resorc[4]arenu s chloridem boritým byla připravena směs parciálně alkylovaných derivátů. Jejich konformační chování bylo studováno 1H NMR spektroskopií a kvantově-chemickými výpočty. Byla nalezena interkonverze dvou možných identických crown konformérů (flip-flop inverze). Aktivační energie procesu závisí na počtu hydroxylových skupin v molekule. Tato inverze nebyla pozorována pro sloučeninu s volnými hydroxyskupinami a pro monoalkylether. Molekulové modelování potvrdilo, že inverze probíhá přes postupnou rotaci dvou spojených kruhů.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Organic Chemistry

  • ISSN

    1434-193X

  • e-ISSN

  • Volume of the periodical

    2006

  • Issue of the periodical within the volume

    19

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    9

  • Pages from-to

    4519-4527

  • UT code for WoS article

  • EID of the result in the Scopus database