Short-term effect of soy consumption on thyroid hormone levels and correlation with phytoestrogen level in healthy subjects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F08%3A00021166" target="_blank" >RIV/60461373:22330/08:00021166 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/08:#0000246

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Short-term effect of soy consumption on thyroid hormone levels and correlation with phytoestrogen level in healthy subjects

Original language description

Objective. Since soy isoflavones may influence the thyroid hormone feedback system by interference with their biosynthesis, secretion and metabolism, we tested whether their controlled shortterm consumption affects thyroid function. Methods. Eighty six volunteers - university students (32 males and 54 females) were eating unprocessed boiled natural soybeans (2 g/kg body weight/day) for 7 consecutive days. Thyrotropin, free thyroid hormones, antibodies to thyroid peroxidase and to thyroglobulin, and actual levels of unconjugated major soy phytoestrogens, daidzein and genistein, were measured in sera collected before, at the end and one week after finishing soy meal consumption. Results. Both phytoestrogens increased significantly (p<0.0001) at the end of soy-diet and fell down after its termination nearly back to the initial values. No significant changes were found in female group, while in males a significant transitory increase of thyrotropin (p<0.0001) was recorded. When actual leve

Czech name

Krátkodobý účinek konzumace soji na koncentrace thyroidálních hormonů a korelace s fytoestrogeny u zdravých osob

Czech description

Osmdesát šest dobrovolníků - univerzitních studentů (32 mužů a 54 žen) konzumovalo sojové boby (2 g/kg tělesné hmotnosti) po 7 dnů. Byly u nich měřeny thyrotropin, T3, T4, proptilátky proti thyroidální peroxidase a aktuální hladiny hlavních sojových fytoestrogenů, daidzeinu a genisteinu. U žen nebyly pozorovány žádné statisticky významné změny thyroidálních hormonů, u mužů bylo zaznamenáno přecodné zvýšení thyrotropinu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/GA303%2F08%2F0958" target="_blank" >GA303/08/0958: Phytoestrogens as an Alternative to Hormone Replacement Therapy - An Efficiency and Safety Study</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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