Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43891709" target="_blank" >RIV/60461373:22330/11:43891709 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives
Original language description
Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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