Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43892100" target="_blank" >RIV/60461373:22330/11:43892100 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/11:00365267
Result on the web
<a href="http://dx.doi.org/10.1016/j.jcis.2011.05.084" target="_blank" >http://dx.doi.org/10.1016/j.jcis.2011.05.084</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcis.2011.05.084" target="_blank" >10.1016/j.jcis.2011.05.084</a>

Result language
angličtina
Original language name
Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates
Original language description
An efficient synthesis of three novel stigmasterol-amino acid (glycine, L-leucine and L-phenylalanine) conjugates as stimuli responsive gelators is reported. The gelation properties of the prepared compounds were investigated in a variety of organic as well as aqueous solvents. The most striking finding of our investigation was that the hydrochloride salts of the prepared conjugates acted as gelators, whereas the neutral conjugates were either non-gelators or formed only a weak gel in anisole. The hydrochloride salts of stigmasteryl glycinate and L-Ieucinate form gels in n-alcohols (n = 4-10) and in ethane-1,2-diol, and that of stigmasteryl L-phenylalaninate forms gels in aromatic solvents and in tetrachloromethane. These unique properties of the gelators were explored to prepare stimuli responsive, "acid-base" triggered reversible sol-gel transitions. The gelators and their gels were characterized by liquid and solid-state NMR as well as FT-IR.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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