De novo design of short peptides with antimicrobial activity and the effect of acyl conjugation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43893975" target="_blank" >RIV/60461373:22330/12:43893975 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
De novo design of short peptides with antimicrobial activity and the effect of acyl conjugation
Original language description
The alarming increase in number of resistant pathogenic microorganisms is the reason for the intense search for new antimicrobial agents. The short peptides belong among the newly discovered antimicrobial compounds. These peptides provide a large potential for fight against adaptable pathogens, but in few aspects, like production costs, longer peptides are disadvantageous compared to antibiotics. As potential therapeutic agents, short peptides with simple amino acid composition can be better candidates.We designed three peptides composed of six kinds of amino acids selected on the basis of statistical data from databases to gain amphipathic character and positive charge of peptides. The sequence of amino acids was arranged by three different ways, onewas based on relative frequency of occurrence of residues, to form helical conformation and all of these peptides were modified by C-terminal amidation. To investigate the importance of increased hydrophobicity at the amino end of peptid
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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