The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43894073" target="_blank" >RIV/60461373:22330/12:43894073 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/12:#0000233
Result on the web
<a href="http://dx.doi.org/10.1016/j.fct.2012.05.037" target="_blank" >http://dx.doi.org/10.1016/j.fct.2012.05.037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fct.2012.05.037" target="_blank" >10.1016/j.fct.2012.05.037</a>

Result language
angličtina
Original language name
The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function
Original language description
Dietary supplements used by women during menopause are usually based on plant extracts containing isoflavonoids, daidzein and genistein. Genistein is a known inhibitor of many enzymes, including thyroid peroxidase (TPO). In the thyroid follicle, genistein acts as its alternate substrate for the formation of genistein iodinated derivatives. The aim of this study was to search for daidzein- and genistein-iodinated derivatives in urine of isoflavonoid-supplemented women. Additionally, selected phytoestrogens, steroid and thyroid hormones before and after three months of phytoestrogen supplementation were estimated. Urinary levels of free phytoestrogen increased significantly after therapy. They ranged between 0.3-1600, 0.6-670 and 0-206 nmol/L for daidzein, genistein and S-equol, respectively. Monoiodinated derivatives of genistein were observed (0-504 pmol/L) in 60% of the investigated samples. Steroid and thyroid hormone levels were within the normal range and were not significantly alt
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/GA303%2F08%2F0958" target="_blank" >GA303/08/0958: Phytoestrogens as an Alternative to Hormone Replacement Therapy - An Efficiency and Safety Study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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