Design and studies of novel polyoxysterol-based porphyrin conjugates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43894135" target="_blank" >RIV/60461373:22330/12:43894135 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.steroids.2012.07.005" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2012.07.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2012.07.005" target="_blank" >10.1016/j.steroids.2012.07.005</a>

Result language
angličtina
Original language name
Design and studies of novel polyoxysterol-based porphyrin conjugates
Original language description
New types of steroid-porphyrin conjugates derived from 20-hydroxyecdysone (20E) and 24-epibrassinolide (EBI) were synthesized. An exceptional regioselectivity in the reaction of both steroids with porphyrin boronic acids was found to give side-chain-conjugated boronic esters as sole products. UV-Vis-, fluorescence and NMR spectroscopy yielded similar data for all the studied compounds confirming the solvent driven supramolecular assembly with formation of J-aggregates. CD measurements of water diluted solutions showed a clear difference between 20E and EBI conjugates. The latter showed a strong supramolecular chirality, whereas 20E J-aggregates did not.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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