Nutritional regulation of adipose tissue lipoprotein lipase is blunted in insulin resistant rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43894327" target="_blank" >RIV/60461373:22330/12:43894327 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/12:00056348
Result on the web
<a href="http://dx.doi.org/10.2478/s11535-012-0002-y" target="_blank" >http://dx.doi.org/10.2478/s11535-012-0002-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11535-012-0002-y" target="_blank" >10.2478/s11535-012-0002-y</a>
Alternative languages
Result language
angličtina
Original language name
Nutritional regulation of adipose tissue lipoprotein lipase is blunted in insulin resistant rats
Original language description
Background: Hypertriglyceridemia is a common lipid abnormality accompanying insulin resistance. This study was designed to assess the contribution of dysregulation of adipose tissue lipoprotein lipase (LPL) activity to the hypertriglyceridemia in a rat model of insulin resistance. Methodology: Hereditary hypertriglyceridemic (HHTg) rats were challenged for two weeks on a high sucrose diet and LPL activity, angptl-4 expression and FFA utilisation in vitro were determined in adipose tissue. Results: Compared to control rats (Wistar), HHTg rats exhibited hyperinsulinemia, impaired fatty acid storage in adipose tissue and elevated LPL activity both in fasting and after refeeding. The expression of angiopoietin-like protein 4 (angptl4), a fasting-induced control protein for LPL activity, was not increased in adipose tissue of fasted HHTg rats as it was in the control rats. Conclusion: We conclude that LPL remains in its active form to a higher extent in HHTg rat adipose tissue due to the lo
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9696" target="_blank" >NS9696: Mechanisms and consequences of the accumulation of lipids in liver associated with metabolic syndrome - the possibilities of nutritional and pharmacological intervention</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Central European Journal Of Biology
ISSN
1895-104X
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
2
Country of publishing house
PL - POLAND
Number of pages
9
Pages from-to
201-209
UT code for WoS article
000302476500003
EID of the result in the Scopus database
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