On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43898328" target="_blank" >RIV/60461373:22330/14:43898328 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2014/706269" target="_blank" >http://dx.doi.org/10.1155/2014/706269</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/706269" target="_blank" >10.1155/2014/706269</a>
Alternative languages
Result language
angličtina
Original language name
On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
Original language description
Resveratrol-3,5,4 '-trihydroxystilbene-possesses antioxidant activities in vitro. It dose-dependently inhibited the generation of peroxyl, hydroxyl, peroxides, and lipid peroxidation products in cell free systems. Oxidative burst of whole human blood stimulated with PMA, fMLP, OpZ, and A23187 was inhibited in a concentration-dependent way, indicating suppression of both receptor and nonreceptor activated chemiluminescence by resveratrol. Results from isolated human neutrophils revealed that resveratrolwas active extracellularly as well as intracellularly in inhibiting the generation of reactive oxygen species. Liberation of ATP and analysis of apoptosis showed that in the concentration of 100 mu M, resveratrol did not change the viability and integrity of isolated neutrophils. Western blot analysis documented that resveratrol in concentrations of 10 and 100 mu M significantly decreased PMA-induced phosphorylation of PKC alpha/beta II. Dose-dependent inhibition of nitrite production an
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oxidative Medicine and Cellular Longevity
ISSN
1942-0994
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
2014 - Article ID 706269
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000330936400001
EID of the result in the Scopus database
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