PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899649" target="_blank" >RIV/60461373:22330/15:43899649 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/acp/2015/746856/" target="_blank" >http://www.hindawi.com/journals/acp/2015/746856/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/746856" target="_blank" >10.1155/2015/746856</a>
Alternative languages
Result language
angličtina
Original language name
PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women
Original language description
Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. Loss of PTEN function has been implicated in the pathogenesis of a number of different tumors, particularly endometrial carcinoma (ECa). ECa is the most common neoplasia of the female genital tract. Our study evaluates an association between the morphological appearance of endometrial hyperplasia and endometrial carcinoma and the degree of PTEN alterations. A total of 45 endometrial biopsies from Slovak women were included in present study. Formalin-fixed and paraffin-embedded tissue samples with simple hyperplasia (3), complex hyperplasia (5), atypical complex hyperplasia (7), endometrioid carcinomas G1 (20) and G3 (5), and serous carcinoma (5) were evaluated for the presence of mutations in coding regions of PTEN gene, the most frequently mutated tumor suppressor gene in endometrial carcinoma. 75% of the detected
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analytical Cellular Pathology
ISSN
2210-7177
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
květen 2015
Country of publishing house
EG - EGYPT
Number of pages
7
Pages from-to
"nestrankovano"
UT code for WoS article
000356424500001
EID of the result in the Scopus database
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