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Study of Cytotoxic Effects of Benzonitrile Pesticide

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899902" target="_blank" >RIV/60461373:22330/15:43899902 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.hindawi.com/journals/bmri/2015/381264" target="_blank" >http://www.hindawi.com/journals/bmri/2015/381264</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2015/381264" target="_blank" >10.1155/2015/381264</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of Cytotoxic Effects of Benzonitrile Pesticide

  • Original language description

    The benzonitrile herbicides bromoxynil, chloroxynil, dichlobenil and ioxynil have been used actively worldwide to control weeds in agriculture since 1970s. Even that dichlobenil is prohibited in EU since 2008, studies addressing the fate of benzonitrileherbicides in the environment show that some metabolites of these herbicides are very persistent. We tested the cytotoxic effects of benzonitrile herbicides and their microbial metabolites using two human cell lines Hep G2 and HEK293T, representing liverand kidneys as potential target organs in humans. The cell viability and proliferation was determined by MTT test and RTCA DP Analyzer system, respectively. The latter allows real time monitoring of the effect of added substances. As the cytotoxic compounds could compromise cell membrane integrity, the lactate dehydrogenase test was performed as well. We observed high toxic effects of bromoxynil, chloroxynil and ioxynil on both tested cell lines. In contrast, we determined only low inhi

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA13-28283S" target="_blank" >GA13-28283S: Bridging microbial community ecology and degradation of xenobiotics – the use of metagenomics to investigate microbial degradation potential</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BIOMED RESEARCH INTERNATIONAL

  • ISSN

    2314-6133

  • e-ISSN

  • Volume of the periodical

    2015

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    381264-381273

  • UT code for WoS article

    000359548400001

  • EID of the result in the Scopus database