Study of Cytotoxic Effects of Benzonitrile Pesticide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899902" target="_blank" >RIV/60461373:22330/15:43899902 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/bmri/2015/381264" target="_blank" >http://www.hindawi.com/journals/bmri/2015/381264</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/381264" target="_blank" >10.1155/2015/381264</a>
Alternative languages
Result language
angličtina
Original language name
Study of Cytotoxic Effects of Benzonitrile Pesticide
Original language description
The benzonitrile herbicides bromoxynil, chloroxynil, dichlobenil and ioxynil have been used actively worldwide to control weeds in agriculture since 1970s. Even that dichlobenil is prohibited in EU since 2008, studies addressing the fate of benzonitrileherbicides in the environment show that some metabolites of these herbicides are very persistent. We tested the cytotoxic effects of benzonitrile herbicides and their microbial metabolites using two human cell lines Hep G2 and HEK293T, representing liverand kidneys as potential target organs in humans. The cell viability and proliferation was determined by MTT test and RTCA DP Analyzer system, respectively. The latter allows real time monitoring of the effect of added substances. As the cytotoxic compounds could compromise cell membrane integrity, the lactate dehydrogenase test was performed as well. We observed high toxic effects of bromoxynil, chloroxynil and ioxynil on both tested cell lines. In contrast, we determined only low inhi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-28283S" target="_blank" >GA13-28283S: Bridging microbial community ecology and degradation of xenobiotics – the use of metagenomics to investigate microbial degradation potential</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
381264-381273
UT code for WoS article
000359548400001
EID of the result in the Scopus database
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