ERVW-1 gene polymorphisms related to preeclampsia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43901854" target="_blank" >RIV/60461373:22330/16:43901854 - isvavai.cz</a>
Result on the web
<a href="https://www.researchgate.net/profile/Petra_Priscakova/publication/306383609_ERVW-1_gene_polymorphisms_related_to_preeclampsia/links/5829789508ae5c0137f3e2a3.pdf?origin=publication_list" target="_blank" >https://www.researchgate.net/profile/Petra_Priscakova/publication/306383609_ERVW-1_gene_polymorphisms_related_to_preeclampsia/links/5829789508ae5c0137f3e2a3.pdf?origin=publication_list</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2016_067" target="_blank" >10.4149/BLL_2016_067</a>
Alternative languages
Result language
angličtina
Original language name
ERVW-1 gene polymorphisms related to preeclampsia
Original language description
OBJECTIVES: Identification of genetic association between the gene ERVW-1 and preeclampsia. BACKGROUND: Preeclampsia is a multifactorial disease affecting women during pregnancy and it is one of the main causes of perinatal and maternal morbidity and mortality. The pathophysiology of preeclampsia is very complex and several aspects of the disease have not been elucidated yet. Abnormal placentation frequently occurs during severe preeclampsia. Protein syncytin 1, a product of the ERVW-1 gene, plays a crucial role in the syncytiotrophoblast differentiation and optimal placentation. The syncytin 1 expression is disturbed during preeclampsia. The main focus of this study was the analysis of the ERVW-1 regulatory regions and identification of DNA polymorphisms associated with preeclamptic cases in Slovak population.. METHODS: Regulatory region of gene ERVW-1 was analyzed by sequencing to identify genetic variants. RESULTS: We identified four DNA variants, namely rs4727276, rs148592540, rs569899772 and rs555416193, in samples of Slovak population. CONCLUSION: No relation between polymorphisms and preeclampsia was observed, indicating that further investigations with a larger sampling are still required. However, our work represents new original approach in genetic differential diagnosis of preeclampsia with possible useful findings in the future (Tab. 3, Fig. 1, Ref. 34).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislava Medical Journal-BRATISLAVSKE LEKARSKE LISTY
ISSN
0006-9248
e-ISSN
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Volume of the periodical
117
Issue of the periodical within the volume
6
Country of publishing house
SK - SLOVAKIA
Number of pages
5
Pages from-to
340-344
UT code for WoS article
000378300700008
EID of the result in the Scopus database
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