Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43901855" target="_blank" >RIV/60461373:22330/16:43901855 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/16:00465951 RIV/00216208:11110/16:10327684 RIV/00023761:_____/16:N0000030 RIV/00064165:_____/16:10327684
Result on the web
<a href="https://www.hindawi.com/journals/omcl/2016/6190609/" target="_blank" >https://www.hindawi.com/journals/omcl/2016/6190609/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/6190609" target="_blank" >10.1155/2016/6190609</a>
Alternative languages
Result language
angličtina
Original language name
Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
Original language description
Mild constitutive hyperbilirubinemia is associated with a reduced risk of cardiovascular diseases, diabetes, and cancer. Since these pathologies are associated with aging, inflammation, and oxidative stress, we investigated whether hyperbilirubinemia interferes with ROS homeostasis in cell cultures and with inflammation, senescence, and mitochondrial dysfunction in aged rats. Human embryonic kidney cells and rat primary fibroblasts showed a dose-dependent decrease in the ratio of oxidized/reduced glutathione, intracellular H2O2 levels, and mitochondrial ROS production, with increasing bilirubin concentrations in the culture media. Compared to their normobilirubinemic siblings, aged hyperbilirubinemic Gunn rats showed significantly smaller amounts of visceral fat, better glucose tolerance, and decreased serum levels of proinflammatory cytokines TNF alpha, IL-1 beta, and IL-18. Simultaneously, livers from Gunn rats showed decreased expression of senescence markers and cell cycle inhibitors p21 and p16. Mitochondria from aged Gunn rats showed higher respiration and lower H2O2 production compared to controls. In conclusion, we demonstrated that mildly elevated serum bilirubin is generally associated with attenuation of oxidative stress and with better anthropometric parameters, decreased inflammatory status, increased glucose tolerance, fewer signs of cellular senescence, and enhanced mitochondrial function in aged rats.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GPP305%2F12%2FP388" target="_blank" >GPP305/12/P388: Mitochondrial DNA in tumors and metabolic syndrome</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oxidative Medicine and Cellular Longevity
ISSN
1942-0900
e-ISSN
—
Volume of the periodical
Neuveden
Issue of the periodical within the volume
léto 2016
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"nestrankovano"
UT code for WoS article
000381431600001
EID of the result in the Scopus database
2-s2.0-84986247533