Equol Effectively Inhibits Toxic Activity of Human Neutrophils without Influencing Their Viability

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43902580" target="_blank" >RIV/60461373:22330/16:43902580 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/16:00458997

Result on the web

<a href="http://www.karger.com/Article/Abstract/443177" target="_blank" >http://www.karger.com/Article/Abstract/443177</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000443177" target="_blank" >10.1159/000443177</a>

Result language

angličtina

Original language name

Equol Effectively Inhibits Toxic Activity of Human Neutrophils without Influencing Their Viability

Original language description

Equol (7,4'-dihydroxy-isoflavan, or 4',7-isoflavandiol) is a chroman derivative produced by intestinal bacteria in response to soy isoflavone intake in some, but not in all, humans. Equol shows strong anti-oxidant, anti-estrogenic, anti-cancerous and anti-inflammatory properties. The antioxidative capacity of equol has recently received considerable attention, and it has been used for preventing and treating several diseases. We investigated the effect of equol on human neutrophils, extra- and intracellular formation of oxidants, the phosphorylation of protein regulating NADPH oxidase and its effect on apoptosis. Neutrophils, isolated from blood from healthy subjects, were tested upon activation with various stimulants, proper for reactive oxygen species (ROS) production and treated by equol. Equol has the ability to reduce the toxic action of neutrophils. With increasing concentrations, equol decreased the amount of oxidants produced by neutrophils both extra-and intracellularly. The phosphorylation of p40(phox) (a component of NADPH oxidase, responsible for the assembly of functional oxidase in intracellular membranes) was reduced in the presence of equol. The experiments showed that equol did not change the number of viable, apoptotic or dead neutrophils significantly in all concentrations used. These results indicate the promising effect of equol in the operation of ROS in different mechanisms in the model of inflammation. (C) 2016 S. Karger AG, Basel

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PHARMACOLOGY

ISSN

0031-7012

e-ISSN

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Volume of the periodical

97

Issue of the periodical within the volume

3-4

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

138-145

UT code for WoS article

000371351400006

EID of the result in the Scopus database

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