Targeting of stress response pathways in the prevention and treatment of cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F18%3A43917387" target="_blank" >RIV/60461373:22330/18:43917387 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0734975018300077" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0734975018300077</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biotechadv.2018.01.007" target="_blank" >10.1016/j.biotechadv.2018.01.007</a>
Alternative languages
Result language
angličtina
Original language name
Targeting of stress response pathways in the prevention and treatment of cancer
Original language description
The hallmarks of tumor tissue are not only genetic aberrations but also the presence of metabolic and oxidative stress as a result of hypoxia and lactic acidosis. The stress activates several prosurvival pathways including metabolic remodeling, autophagy, antioxidant response, mitohormesis, and glutaminolysis, whose upregulation in tumors is associated with a poor survival of patients, while their activation in healthy tissue with statins, metformin, physical activity, and natural compounds prevents carcinogenesis. This review emphasizes the dual role of stress response pathways in cancer and suggests the integrative understanding as a basis for the development of rational therapy targeting the stress response.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LO1601" target="_blank" >LO1601: Prague University Analytical Centre II and III - NPU 2015-2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biotechnology Advances
ISSN
0734-9750
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
583-602
UT code for WoS article
000432104800004
EID of the result in the Scopus database
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