Total synthesis of inubosin B

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43922235" target="_blank" >RIV/60461373:22330/20:43922235 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/20:00535965
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0040403920311461?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0040403920311461?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetlet.2020.152641" target="_blank" >10.1016/j.tetlet.2020.152641</a>

Result language
angličtina
Original language name
Total synthesis of inubosin B
Original language description
Inubosin B is the most active member of the acridine alkaloids isolated from Streptomyces sp. IFM 11440 culture. The inubosins initiate neuroregeneration via a neurogenine 2 pathway. In this work, we have described the total synthesis of inubosin B via two synthetic routes. The effects of various coupling, cyclization and reduction reactions are discussed including common pitfalls and side reactions. Reverse phase chromatography with TFA was crucial for the isolation of the product from aluminum ions present in the reduction media. © 2020 Elsevier Ltd
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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