Protease Inhibitors as Chemotherapeutics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43934141" target="_blank" >RIV/60461373:22330/20:43934141 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/20:00532406
Result on the web
<a href="http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3668/3604" target="_blank" >http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3668/3604</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
čeština
Original language name
Inhibitory proteas jako chemoterapeutika
Original language description
Proteolytic enzymes (peptidases or proteases) are involved in a wide range of human pathologies. Therefore, they represent molecular targets for therapeutic intervention, and protease inhibitors are promising chemotherapeutics. These inhibitory drugs are typically developed as small-molecule compounds that block the protease active site. In this area, pharmaceutical research has achieved a number of successes over the past 30 years, and several dozen protease inhibitors are currently used in clinical practice or are in advanced clinical trials. This review focuses on the most important areas of their application, including the treatment of hypertension, diabetes, hepatitis C, AIDS, Alzheimer's disease, and cancer.
Czech name
Inhibitory proteas jako chemoterapeutika
Czech description
Proteolytic enzymes (peptidases or proteases) are involved in a wide range of human pathologies. Therefore, they represent molecular targets for therapeutic intervention, and protease inhibitors are promising chemotherapeutics. These inhibitory drugs are typically developed as small-molecule compounds that block the protease active site. In this area, pharmaceutical research has achieved a number of successes over the past 30 years, and several dozen protease inhibitors are currently used in clinical practice or are in advanced clinical trials. This review focuses on the most important areas of their application, including the treatment of hypertension, diabetes, hepatitis C, AIDS, Alzheimer's disease, and cancer.
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemické listy
ISSN
0009-2770
e-ISSN
1213-7103
Volume of the periodical
114
Issue of the periodical within the volume
8
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
515-522
UT code for WoS article
000558763200002
EID of the result in the Scopus database
2-s2.0-85090661274