High Prevalence of Likely Passively Acquired Anti-TPO and Anti-GAD Autoantibodies in Common Variable Immunodeficiency

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922209" target="_blank" >RIV/60461373:22330/21:43922209 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/22:10434130 RIV/00064203:_____/22:10434130 RIV/00216208:11110/22:10434130
Result on the web
<a href="https://link-springer-com.ezproxy.vscht.cz/article/10.1007%2Fs10875-021-01171-8" target="_blank" >https://link-springer-com.ezproxy.vscht.cz/article/10.1007%2Fs10875-021-01171-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10875-021-01171-8" target="_blank" >10.1007/s10875-021-01171-8</a>

Result language
angličtina
Original language name
High Prevalence of Likely Passively Acquired Anti-TPO and Anti-GAD Autoantibodies in Common Variable Immunodeficiency
Original language description
Common variable immunodeficiency disorder (CVID) is one of the most frequent inborn errors of immunity characterized by decreased immunoglobulin production, impaired specific antibody response, and higher susceptibility to infections along with immune system dysregulation and higher prevalence of non-infectious complications [1]. Despite the markedly impaired antibody production, diseases hallmarked by the presence of autoantibodies, such as autoimmune hemolytic anemia (AIHA) or immune thrombocytopenic purpura (ITP), are among the most commonly diagnosed autoimmune complications in CVID patients [2]. The mainstay of CVID management is a regular, long-term immunoglobulin replacement therapy (IRT). Importantly, the immunoglobulin solutions used for IRT were shown to contain various specific antibodies and may even be responsible for IRT-associated adverse events, such as self-limiting acute hemolysis triggered by passivelly transmitted antierythrocyte alloantibodies [3]. Therefore, we initiated a prospective observational trial to determine the prevalence, clinical significance, and origin of the spectrum of autoantibodies in CVID patients on IRT.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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