Synergistic Inhibitory Effect of Chitosan and Amphotericin B on Planktonic and Biofilm Populations of C. albicans, C. parapsilosis and C. krusei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922996" target="_blank" >RIV/60461373:22330/21:43922996 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1134/S0026261721030061" target="_blank" >https://link.springer.com/article/10.1134/S0026261721030061</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1134/S0026261721030061" target="_blank" >10.1134/S0026261721030061</a>
Alternative languages
Result language
angličtina
Original language name
Synergistic Inhibitory Effect of Chitosan and Amphotericin B on Planktonic and Biofilm Populations of C. albicans, C. parapsilosis and C. krusei
Original language description
Abstract: Many microorganisms readily form microbial biofilms whose resistance to antimicrobial compounds is several orders of magnitude higher than that of the planktonic form. One such genus is the yeast Candida, whose species include both human commensals and opportunistic pathogens that are the cause of many fungal infections. Increasing efforts are therefore made to find substances that could replace currently used drugs, or synergistically interact with them and therefore reinforce their action at an acceptable concentration against both cell suspensions and biofilm populations. We investigated the effect of natural-derived compounds chitosan and a commonly used antibiotic amphotericin B against Candida albicans, C. parapsilosis and C. krusei. Chitosan has proven to be a very effective agent against all Candida species both in suspensions and in biofilm formation and eradication. A combination of chitosan and amphotericin B had a strong synergistic effect even at low concentrations. We achieved the reduction of effective concentration of amphotericin B for inhibition of formation and eradication of Candida spp. biofilm, which may be utilized in medicine as an effective approach in lessening the antibiotic concentrations needed for successful treatment. © 2021, Pleiades Publishing, Ltd.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microbiology
ISSN
1350-0872
e-ISSN
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Volume of the periodical
90
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
370-382
UT code for WoS article
000659194400009
EID of the result in the Scopus database
2-s2.0-85107564631