Synthesis of phosphonate derivatives of 2 '-deoxy-2 '-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43933937" target="_blank" >RIV/60461373:22330/21:43933937 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/21:00543389
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0040402021003458?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0040402021003458?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tet.2021.132159" target="_blank" >10.1016/j.tet.2021.132159</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of phosphonate derivatives of 2 '-deoxy-2 '-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides
Original language description
Analogs of nucleosides and nucleotides represent a promising pool of potential therapeutics. This work describes a new synthetic route leading to 2 '-deoxy-2 '-fluorotetradialdose D-nucleoside phosphonates. Moreover, a new universal synthetic route leading to tetradialdose D-nucleosides bearing purine nucleobases is also described. All new compounds were tested as triphosphate analogs for inhibitory potency against a variety of viral polymerases. The fluorinated nucleosides were transformed to phosphoramidate prodrugs and evaluated in cell cultures against various viruses including influenza and SARS-CoV-2. (C) 2021 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
TETRAHEDRON
ISSN
0040-4020
e-ISSN
1464-5416
Volume of the periodical
89
Issue of the periodical within the volume
4. června 2021
Country of publishing house
IE - IRELAND
Number of pages
18
Pages from-to
nestránkováno
UT code for WoS article
000659206000014
EID of the result in the Scopus database
2-s2.0-85104947933