Critical comparison of direct analysis in real time orbitrap mass spectrometry (DART-Orbitrap MS) towards liquid chromatography mass spectrometry (LC-MS) for mycotoxin detection in cereal matrices
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925102" target="_blank" >RIV/60461373:22330/22:43925102 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.foodcont.2021.108548" target="_blank" >https://doi.org/10.1016/j.foodcont.2021.108548</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.foodcont.2021.108548" target="_blank" >10.1016/j.foodcont.2021.108548</a>
Alternative languages
Result language
angličtina
Original language name
Critical comparison of direct analysis in real time orbitrap mass spectrometry (DART-Orbitrap MS) towards liquid chromatography mass spectrometry (LC-MS) for mycotoxin detection in cereal matrices
Original language description
Foodstuffs contaminated by mycotoxins have been reported around the globe resulting in significant financial losses and health-threating cases due to dietary exposure. Commonly, two analytical approaches are used in mycotoxin analysis, namely screening bioanalytical methods such as immunoassays and confirmatory chromatographic analysis which are related to certain merits and challenges. In this study, to provide an alternative combining rapidness and unequivocal analyte identification, a direct analysis in real time ion source coupled to orbitrap mass spectrometry (DART-Orbitrap MS) method was developed and validated for the detection of 19 mycotoxins in cereal flour matrices. Excellent detectability expressed as the lowest calibration level (LCL) ranging between 25 μg kg−1 and 250 μg kg−1 depending on the analyte was achieved as well as satisfactory precision and trueness. To identify advantages and drawbacks of the in-house DART-Orbitrap MS method against the golden standard methods, a critical comparison towards liquid chromatography (LC) coupled to high and low resolution MS was performed. DART-Orbitrap MS high throughput and rapidity was revealed while LC-MS proved its superior detectability, which is of indispensable importance for mycotoxin regulatory control. In conclusion, the developed DART-Orbitrap MS method can be applied to intensify and accelerate the monitoring of specific mycotoxins in cereal matrices. © 2021 Elsevier Ltd
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/LM2018100" target="_blank" >LM2018100: Infrastructure for Promoting Metrology in Food and Nutrition in the Czech Republic</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food control
ISSN
0956-7135
e-ISSN
1873-7129
Volume of the periodical
132
Issue of the periodical within the volume
FEB 2022
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
nestrankovano
UT code for WoS article
000702859600003
EID of the result in the Scopus database
2-s2.0-85115759781