Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925554" target="_blank" >RIV/60461373:22330/22:43925554 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1368764622000437?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1368764622000437?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.drup.2022.100844" target="_blank" >10.1016/j.drup.2022.100844</a>

Result language

angličtina

Original language name

Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents

Original language description

Selenium is an essential trace element that is crucial for cellular antioxidant defense against reactive oxygen species (ROS). Recently, many selenium-containing compounds have exhibited a wide spectrum of biological activities that make them promising scaffolds in Medicinal Chemistry, and, in particular, in the search for novel compounds with anticancer activity. Similarly, certain tellurium-containing compounds have also exhibited substantial biological activities. Here we provide an overview of the biological activities of seleno- and tellurocompounds including chemopreventive activity, antioxidant or pro-oxidant activity, modulation of the inflammatory processes, induction of apoptosis, modulation of autophagy, inhibition of multidrug efflux pumps such as P-gp, inhibition of cancer metastasis, selective targeting of tumors and enhancement of the cytotoxic activity of chemotherapeutic drugs, as well as overcoming tumor drug resistance. A review of the chemistry of the most relevant seleno- or tellurocompounds with activity against resistant cancers is also presented, paying attention to the synthesis of these compounds and to the preparation of bioactive selenium or tellurium nanoparticles. Based on these data, the use of these seleno- and tellurocompounds is a promising approach in the development of strategies that can drive forward the search for novel therapies or adjuvants of current therapies against drug-resistant cancers.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/LTC19007" target="_blank" >LTC19007: Testing of the new compounds with potential for resistance modulation in multi drug resistant strains</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Resistance Updates

ISSN

1368-7646

e-ISSN

1532-2084

Volume of the periodical

63

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

24

Pages from-to

nestrankovano

UT code for WoS article

000799161200001

EID of the result in the Scopus database

2-s2.0-85129637262