Targeting the Virus Capsid as a Tool to Fight RNA Viruses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925555" target="_blank" >RIV/60461373:22330/22:43925555 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1999-4915/14/2/174" target="_blank" >https://www.mdpi.com/1999-4915/14/2/174</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/v14020174" target="_blank" >10.3390/v14020174</a>

Result language

angličtina

Original language name

Targeting the Virus Capsid as a Tool to Fight RNA Viruses

Original language description

Several strategies have been developed to fight viral infections, not only in humans but also in animals and plants. Some of them are based on the development of efficient vaccines, to target the virus by developed antibodies, others focus on finding antiviral compounds with activities that inhibit selected virus replication steps. Currently, there is an increasing number of antiviral drugs on the market; however, some have unpleasant side effects, are toxic to cells, or the viruses quickly develop resistance to them. As the current situation shows, the combination of multiple antiviral strategies or the combination of the use of various compounds within one strategy is very important. The most desirable are combinations of drugs that inhibit different steps in the virus life cycle. This is an important issue especially for RNA viruses, which replicate their genomes using error-prone RNA polymerases and rapidly develop mutants resistant to applied antiviral compounds. Here, we focus on compounds targeting viral structural capsid proteins, thereby inhibiting virus assembly or disassembly, virus binding to cellular receptors, or acting by inhibiting other virus replication mechanisms. This review is an update of existing papers on a similar topic, by focusing on the most recent advances in the rapidly evolving research of compounds targeting capsid proteins of RNA viruses.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10607 - Virology

Project

<a href="/en/project/LTAUSA17061" target="_blank" >LTAUSA17061: Fullerene inhibitors of HIV-1</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Viruses

ISSN

1999-4915

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

44

Pages from-to

nestrankovano

UT code for WoS article

000762077100001

EID of the result in the Scopus database

2-s2.0-85123106226