Identifying edible plants with high anti-obesity potential: In vitro inhibitory effect against pancreatic lipase followed by bioactive compound metabolomic screening

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F23%3A43928182" target="_blank" >RIV/60461373:22330/23:43928182 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43926317 RIV/00064173:_____/23:43926317

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2212429223011045?via%3Dihub#ack0010" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2212429223011045?via%3Dihub#ack0010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.fbio.2023.103453" target="_blank" >10.1016/j.fbio.2023.103453</a>

Result language

angličtina

Original language name

Identifying edible plants with high anti-obesity potential: In vitro inhibitory effect against pancreatic lipase followed by bioactive compound metabolomic screening

Original language description

The ever-growing number of individuals facing obesity related health problems represents an alarming situation. Within the available obesity control strategies, there is evidence that some natural compounds can inhibit pancreatic lipase (PNLIP, EC 3.1.1.3), a digestive enzyme with pivotal role in the hydrolysis of dietary triacylglycerols, resulting in reduced fat metabolism. In this study, to identify sources of bioactive compounds with anti-obesity potential, 278 extracts originating by 126 food species were prepared in water and dichloromethane (DCM) and their in vitro inhibitory potential against PNLIP was measured. Importantly, 12 extracts exceeded the set cut-off level of significant inhibitory effect (inhibition&gt; 70%) and for them dose-response curves were prepared and metabolomic target screening was performed. By using ultra-high-performance liquid chromatography hybrid quadrupole time-of-flight mass spectrometry (UHPLC-q-TOF-MS), it was possible to tentatively identify 28 and 22 secondary metabolites in the aqueous and DCM extracts, respectively. Several species-specific compounds were detected, e.g., hesperidin and eriocitrin in lemon and lime fruit aqueous extracts or curcuminoids in DCM turmeric extracts. Additionally, the highest percentage of the total analytical signal detected in dill, walnut, caper and bell pepper DCM extracts corresponded to various fatty acids. All in all, the edible plant extracts with strong anti-obesity potential contained various bioactive phytochemicals that may be used in nutraceutical applications. © 2023 Elsevier Ltd

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30308 - Nutrition, Dietetics

Project

<a href="/en/project/NU21-01-00259" target="_blank" >NU21-01-00259: Novel inhibitors of lipolysis in the treatment of lipid a glucose metabolism in obstructive sleep apnea syndrome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food Bioscience

ISSN

2212-4292

e-ISSN

—

Volume of the periodical

56

Issue of the periodical within the volume

103453

Country of publishing house

ZA - SOUTH AFRICA

Number of pages

11

Pages from-to

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UT code for WoS article

001141618200001

EID of the result in the Scopus database

2-s2.0-85180112860