Challenges of cannabidiol determination in emulsified cosmetics and application of solid‑phase extraction followed by HPLC‑UV‑MS/MS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F25%3A43930219" target="_blank" >RIV/60461373:22330/25:43930219 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/25:43930219
Result on the web
<a href="https://link.springer.com/article/10.1007/s00216-024-05716-9" target="_blank" >https://link.springer.com/article/10.1007/s00216-024-05716-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00216-024-05716-9" target="_blank" >10.1007/s00216-024-05716-9</a>
Alternative languages
Result language
angličtina
Original language name
Challenges of cannabidiol determination in emulsified cosmetics and application of solid‑phase extraction followed by HPLC‑UV‑MS/MS
Original language description
The recent surge in popularity of cannabidiol-infused products extends beyond food and supplements to the cosmetic industry. Accurate labeling remains a significant concern, as many products fail to meet advertised cannabidiol content and/or contain psychoactive tetrahydrocannabinol above the permissible levels. In this work, we present the use of an HPLC-UV-MS/MS method for the quantification of five major cannabinoids (cannabidiol, cannabidiolic acid, tetrahydrocannabinol, tetrahydrocannabinolic acid, and cannabigerol) in oil-in-water cosmetic emulsions. The sample extraction is based on dispersing the sample in isopropanol, followed by solid-phase extraction using Bond Elut Plexa PAX cartridge. The viability of this method is demonstrated by comparing matrix effects in samples subjected to solid-phase extraction (0‒11% suppression of cannabidiol ionization) to samples extracted without additional purification steps (0‒84% ionization suppression of cannabidiol ionization). The limit of quantification is determined at 0.1 mg/g and the calibration is employed in the range of 0.1‒50 mg/g for cannabidiol and 0.1‒10 mg/g for all other analytes. Finally, 36 real cosmetic samples from the Czech market were analyzed. Of these, 14 indicated the amount of CBD on the label but only five (36%) were accurate, i.e., within 90‒110% of the labeled amount, and a considerable amount of THC (0.16 ± 0.01 mg/g) was found in one sample. These findings contribute to the cumulating evidence that cannabidiol-based consumer products are often mislabeled and highlight the importance of better regulatory compliance.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN
1618-2642
e-ISSN
1618-2650
Volume of the periodical
417
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
1153-1163
UT code for WoS article
001390273900001
EID of the result in the Scopus database
2-s2.0-85214120934