Innovative antifungal strategies: enhanced biofilm inhibition of Candida albicans by a modified tea tree oil formulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F25%3A43932151" target="_blank" >RIV/60461373:22330/25:43932151 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1518598/full" target="_blank" >https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1518598/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmicb.2024.1518598" target="_blank" >10.3389/fmicb.2024.1518598</a>

Result language

angličtina

Original language name

Innovative antifungal strategies: enhanced biofilm inhibition of Candida albicans by a modified tea tree oil formulation

Original language description

Introduction Candida albicans is a significant human pathogen with the ability to form biofilms, a critical factor in its resistance to antifungal treatments. This study aims to evaluate the antifungal activity and biofilm inhibition potential of Tea Tree Oil (TTO) derived from Melaleuca alternifolia cultivated in Vietnam.Methods The antifungal activity of TTO was assessed by determining the Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC), Minimum Biofilm Inhibitory Concentration (MBIC), and Minimum Biofilm Eradication Concentration (MBEC) using broth dilution methods. The experiments were conducted on C. albicans in both planktonic and biofilm states across concentrations ranging from 0.1 mu L/mL to 10 mu L/mL.Results TTO demonstrated significant antifungal efficacy, with a MIC of 0.1 mu L/mL (similar to 91.217 mu g/mL) and an MFC of 10 mu L/mL (similar to 9121.7 mu g/mL). It effectively inhibited biofilm formation with a recorded MBIC of 2 mu L/mL (similar to 1824.34 mu g/mL). However, MBEC values were not determinable as the concentrations tested did not achieve the eradication of more than 50% of mature biofilm within the experimental conditions.Discussion These findings highlight TTO as a promising natural antifungal agent with strong biofilm-inhibitory properties. However, its limited efficacy in eradicating mature biofilms underscores the need for further studies, potentially involving higher concentrations or synergistic combinations with conventional antifungal agents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Microbiology

ISSN

1664-302X

e-ISSN

1664-302X

Volume of the periodical

15

Issue of the periodical within the volume

15 January 2025

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

nestránkováno

UT code for WoS article

001408187300001

EID of the result in the Scopus database

2-s2.0-85216320526