Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00007465" target="_blank" >RIV/60461373:22340/03:00007465 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid

Original language description

1-Hydroxyethylidenediphosphonic acid (HEDP), labeled by short-lived radionuclides with the nuclear properties suitable for the therapeutical purposes (186Fe, 188Ho) is similar to the other phosphonates widely applied in the radiopharmaceutical field forthe treatment of palliative bone metastases. One of the important steps for the preparation of compounds of radipharmaceutical interest is the quality control comprehending the radiochemical and chemical purity determination. Chromatographic methods as TLC and HPLC are mostly used for this purpose. Our experiments were focused on the application of capillary electrophoresis with UV detection to the study of rhenium complexation with HEDP. The influence of pH, concentration of the ligand and the reactiontime were determined. Taking in account our previous results, the Re:SnCl2 molar ratio 1.500 (for 0.1 mM Re) was applied to reduce perrhenate to lewer oxidation states which enables the Re-HEDP complexation. Different backround electrolyt

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GA203%2F00%2FD014" target="_blank" >GA203/00/D014: Utilisation of bacteriological and limnological bioassays with marine microorganisms in ecotoxicological monitoring of areas contaminated with organic</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Chromatography A

ISSN

0021-9673

e-ISSN

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Volume of the periodical

990

Issue of the periodical within the volume

990

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

317-323

UT code for WoS article

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EID of the result in the Scopus database

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