Characterisation of Ho-DTPA and Y-DTPA complexes by capillary isotachophoresis and TLC with radiometric detection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00007466" target="_blank" >RIV/60461373:22340/03:00007466 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Characterisation of Ho-DTPA and Y-DTPA complexes by capillary isotachophoresis and TLC with radiometric detection

Original language description

The complexation of holmium and yttrium with DTPA (diethylentriaminepentaacetic acid) was studied as a first step for labelling of monoclonal antibodies for radiopharmaceutical application. Thin-layer chromatography (TLC) with radiometric detection was used to determine the suitable conditions for the preparation of studied complexes. The optimum pH of the reaction mixture, radionuclide ligand ratio, reaction time and stability of selected complex compounds were found. To find out the physico-chemical properties (stability constants) of Ho-DTPA and Y-DTPA complexes the capillary isotachophoresis (cITP) with conductivity detection was applied using the fact that a good linear relationship exists between the stability constants of lanthanide-DTPA complexes and the zone reduction due to tohe blleding effect (liberation of free metal ion). Satisfactory agreement between the stability constant values of Ho-DTPA and Y-DTPA complexes determined by ITP and ones obtained from the JSC Querry Dat

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physical Chemistry A

ISSN

1089-5639

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

53

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

"A63"-"A69"

UT code for WoS article

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EID of the result in the Scopus database

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