Potentiometric Study of Holmium Complexes with EDTMP

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F04%3A00011021" target="_blank" >RIV/60461373:22340/04:00011021 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Potentiometric Study of Holmium Complexes with EDTMP
Original language description
Within the study of 166Ho-complexes as potential radiopharmaceutical agents, stability constantsof those with EDTMP (ethylenediamine-N,N,N´,N´-tetra(methylenephosphonate)) werecalculated by the computer program LETAGROP Etitr using data from potentiometric titrationsmeasured at 25 °C in 0.1 M NaCl. The following values were obtained for stability constantsof Ho-EDTMP complexes Ho(OH)L6#, HoL5#, HHoL4#, H2HoL3#, H3HoL2# and H4HoL#:log = 9.31, 20.22, 28.14, 34.55, 39.89, 45.05, respectively. Diagram of the complex speciationdependence on pH shows that complex forms HHoL4#and H2HoL3# are characteristic ofthe pH range 6#8, which is adequate for their application into the human body.
Czech name
Potenciometrické studium tvorby komplexů holmia s EDTMP
Czech description
Potenciometrickými metodami byla sledována tvorba protonizace kyseliny (ethylenediamine-N,N,N',N'-tetra(methylenfosforečné), EDTPM a tvorba komplexů této kyseliny s Ho3+. Bylo zjištěno, že tato kyselina tvoří s Ho3+ komplexy o složení Ho(OH)L6-, HoL5-, HHoL4 , H2HoL3-, H3HoL2- a H4HoL-, kde L8- je anion EDTMP. Byly stanoveny protonizační konstanty EDTMP (b1 až b6) a konstanty stability nalezených komplexů HopHqL.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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