Raman spectroscopy of tissue samples irradiated by protons
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F04%3A00011227" target="_blank" >RIV/60461373:22340/04:00011227 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/04:00013202 RIV/00216208:11120/04:43906718
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Raman spectroscopy of tissue samples irradiated by protons
Original language description
Purpose: Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. Materials and methods: Tissuesamples of normal skin of mouse and swine, of a human tumour model xenograph, and of normal skin and a skin tumour ( basal cell carcinoma) of a human patient of about 1 mm thickness were irradiated by 24MeV protons ( uniform delivered doses of 1, 7 and 50 Gy: skin of mouse and a human tumour model xenograph, and 0.5, 5 and 50 Gy: swine and human skin). Raman spectra of non-irradiated and irradiated samples were recorded and analysed.Results: Amide I, P=O and C-O bond vibrations and aromatics were sensitive to the proton irradiation dose. In the C-H stretching region, the irradiation-mediated change of Raman spectra was significant only in the case of the skin tumour.Conclusions: It has been shown that Raman spectroscopy is suited to ass
Czech name
Raman spektroskopické studium vlivu protonové radiace na vzorky tkání
Czech description
Účinnost různých dávek záření urychlených protonů na efektivní opracovaní nemocných tkání byla sledovaná Ramanovou spektroskopií. Tkáňové vzorky normální myší, prasečí a lidské kůže byli porovnané se vzorkama nemocných tkáni basal cell karcinomu, adenokarcinomu před a po ozářeni 24 MeV urychlenými protony při 0,5; 1; 5; 7; 50 Gy. Změny v biologickém materiálu vyvolané ozářením urychlenými protony byli prostudovány a diskutovány.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GV301%2F98%2FK042" target="_blank" >GV301/98/K042: Acute monoblastic leukaemia: Analysis of molecular mechanisms and possibilities of targeted regulation</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Radiation Biology
ISSN
0955-3002
e-ISSN
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Volume of the periodical
80
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
581-591
UT code for WoS article
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EID of the result in the Scopus database
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