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Spectroscopic binding studies of novel fluorescent distamycin derivatives

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F08%3A00020630" target="_blank" >RIV/60461373:22340/08:00020630 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Spectroscopic binding studies of novel fluorescent distamycin derivatives

  • Original language description

    Novel distamycin-porphyrin conjugates were synthesized and their interaction with calf thymus DNA was studied. Minor groove binding of the distamycin part of the molecule was confirmed. The porphyrin part of the conjugates exhibited intercalation and thenon-specific electrostatic interaction with the phosphate groups of DNA.

  • Czech name

    Spektroskopická studie nových fluorescenčních derivátů distamycinu

  • Czech description

    Byly syntetizovány nové konjugáty distamycinu a porfyrinu a byla studována jejich interakce s DNA z telecího brzlíku. Bylo potvrzeno, že distamycinová část konjugátu se váže do malého žlábku DNA. Porfyrinová část vykazuje interkalaci a nespecifickou elektrostatickou interakci s fosfátovými skupinami DNA.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Tetrahedron Letters

  • ISSN

    0040-4039

  • e-ISSN

  • Volume of the periodical

    49

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    4

  • Pages from-to

  • UT code for WoS article

    000253006400028

  • EID of the result in the Scopus database