Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F08%3A00020753" target="_blank" >RIV/60461373:22340/08:00020753 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/08:00314797 RIV/00216208:11110/08:1913
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection
Original language description
This paper describes the preparation and use of conjugates of porphyrins and bile acids as ligands to bind to tumor expressed saccharides. Bile acid-porphyrin conjugates were tested for recognition of saccharides that are typically present on malignant tumor cells. Fluorescence microscopy, in vitro PDT cell killing, and PDT of subcutaneous 4T1 mouse tumors is reported. High selectivity for saccharide cancer markers and cancer cells was observed. This in vivo and in vitro study demonstrated high potential use for these compounds in targeted photodynamic therapy.
Czech name
Konjugáty porfirinu a žlučové kyseliny: od rozpoznávání sacharidů k selektivní fluorescenční detekci rakovinných buněk
Czech description
Tento článek popisuje přípravu a použití konjugátů porfirinů a žlučových kyselin jako ligandů, které se vážou na sacharidy tumorů. Studie prokázaly vysoký potenciál použití těchto látek při cílené fotodynamické terapii.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic and Biomolecular Chemistry
ISSN
1477-0520
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
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UT code for WoS article
000255062300005
EID of the result in the Scopus database
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