Model-based scale-up of vacuum contact drying of pharmaceutical compounds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F11%3A43892161" target="_blank" >RIV/60461373:22340/11:43892161 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ces.2011.06.059" target="_blank" >http://dx.doi.org/10.1016/j.ces.2011.06.059</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ces.2011.06.059" target="_blank" >10.1016/j.ces.2011.06.059</a>

Result language

angličtina

Original language name

Model-based scale-up of vacuum contact drying of pharmaceutical compounds

Original language description

An integrated methodology for the scale-up of vacuum contact drying with intermittent agitation is described in this work. The methodology combines a mathematical model of vacuum contact drying, based on differential transient heat and energy balances, and a small-scale experimental apparatus for model validation and parameter estimation. The validated model was used for the estimation of drying times of six different pharmaceutical compounds at the pilot and manufacturing scale over a range of drying conditions - pressure 15-200 mbar, temperature 45-70 degrees C, solvents: acetone, water, methanol, n-propanol, and isopropyl acetate. The mean difference between predicted and actual drying times for the six compounds was less than 9%, which is considered a significant improvement over current semi-empirical approaches to vacuum contact drying scale-up.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Engineering Science

ISSN

0009-2509

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

21

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

5045-5054

UT code for WoS article

000294205800008

EID of the result in the Scopus database

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