Automatic workflow for the classification of local DNA conformations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895100" target="_blank" >RIV/60461373:22340/13:43895100 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/13:00394810 RIV/60461373:22310/13:43895100

Result on the web

<a href="http://www.biomedcentral.com/content/pdf/1471-2105-14-205.pdf" target="_blank" >http://www.biomedcentral.com/content/pdf/1471-2105-14-205.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2105-14-205" target="_blank" >10.1186/1471-2105-14-205</a>

Result language

angličtina

Original language name

Automatic workflow for the classification of local DNA conformations

Original language description

A growing number of crystal and NMR structures reveals a considerable structural polymorphism of DNA architecture going well beyond the usual image of a double helical molecule. DNA is highly variable with dinucleotide steps exhibiting a substantial flexibility in a sequence-dependent manner. An analysis of the conformational space of the DNA backbone and the enhancement of our understanding of the conformational dependencies in DNA are therefore important for full comprehension of DNA structural polymorphism. A detailed classification of local DNA conformations based on the technique of Fourier averaging was published in our previous work. However, this procedure requires a considerable amount of manual work. To overcome this limitation we developed an automatic classification method consisting of the combination of supervised and unsupervised approaches. A proposed workflow is composed of k-NN method followed by a nonhierarchical single-pass clustering algorithm. We applied this work

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JD - Use of computers, robotics and its application

OECD FORD branch

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Project

<a href="/en/project/GAP305%2F12%2F1801" target="_blank" >GAP305/12/1801: Molecular mechanisms of association of a novel type of transposase with repetitive palindromic elements</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Bioinformatics

ISSN

1471-2105

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

205

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1-14

UT code for WoS article

000321006500001

EID of the result in the Scopus database

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