Investigation of pharmaceutical wet granulation in a high-shear mixer and its scale-up with respect to dissolution behaviour

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900436" target="_blank" >RIV/60461373:22340/15:43900436 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Investigation of pharmaceutical wet granulation in a high-shear mixer and its scale-up with respect to dissolution behaviour
Original language description
This work was focused on a high-shear wet granulation process handling formulation containing over 50 % by weight of a hydrophobic Active Pharmaceutical Ingredient (API). This formulation was subjected to parametric sensitivity study and robustness of scale-up was investigated. Effect of both formulation (liquid/solid ratio) and process parameters (agitation rate, chopper rate and wet massing time) was determined at three different scales (0.5, 4.0 and 25 L) with respect to bulk properties of granulatesuch as bulk density and particle size distribution as well as dissolution profiles. Product properties were strongly dependent on the agitation rate, while the chopper rate was a distinctly less important parameter. When agitation rate at a given scalewas fixed, the bulk properties were an increasing function of wet massing time and a steady state was observed. Dissolution rate was a decreasing function of wet massing time. Using the Froude number during scale-up, the bulk density was
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of 42nd International Conference of Slovak Society of Chemical Engineering
ISBN
978-80-89475-14-8
ISSN
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e-ISSN
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Number of pages
9
Pages from-to
"233-1"-"233-9"
Publisher name
J. Markoš, V. Štefuca
Place of publication
Bratislava
Event location
Tatranské Matliare
Event date
May 25, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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