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Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901613" target="_blank" >RIV/60461373:22340/16:43901613 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/16:00465075 RIV/61388971:_____/16:00465861 RIV/61388963:_____/16:00465861 RIV/00216208:11110/16:10325960 and 3 more

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.mce.2016.05.003" target="_blank" >http://dx.doi.org/10.1016/j.mce.2016.05.003</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.mce.2016.05.003" target="_blank" >10.1016/j.mce.2016.05.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination

  • Original language description

    Metformin, vildagliptin and their combination are widely used for the treatment of diabetes, but little is known about the metabolic responses to these treatments. In the present study, NMR-based metabolomics was applied to detect changes in the urinary metabolomic profile of a mouse model of diet-induced obesity in response to these treatments. Additionally, standard biochemical parameters and the expression of enzymes involved in glucose and fat metabolism were monitored. Significant correlations were observed between several metabolites (e.g., N-carbamoyl-beta-alanine, N1-methyl-4-pyridone-3-carboxamide, N1-methyl-2-pyridone-5-carboxamide, glucose, 3-indoxyl sulfate, dimethylglycine and several acylglycines) and the area under the curve of glucose concentrations during the oral glucose tolerance test. The present study is the first to present N-carbamoyl-beta-alanine as a potential marker of type 2 diabetes mellitus and consequently to demonstrate the efficacies of the applied antidiabetic interventions. Moreover, the elevated acetate level observed after vildagliptin administration might reflect increased fatty acid oxidation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular and Cellular Endocrinology

  • ISSN

    0303-7207

  • e-ISSN

  • Volume of the periodical

    431

  • Issue of the periodical within the volume

    C

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    13

  • Pages from-to

    88-100

  • UT code for WoS article

    000379276300009

  • EID of the result in the Scopus database

    2-s2.0-84971222599