Polymorphic Crystallization and Structural Aspects of Agomelatine Metastable Form X Prepared by Combined Antisolvent/Cooling Process
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901963" target="_blank" >RIV/60461373:22340/16:43901963 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/16:43901963
Result on the web
<a href="http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00241" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00241</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.oprd.5b00241" target="_blank" >10.1021/acs.oprd.5b00241</a>
Alternative languages
Result language
angličtina
Original language name
Polymorphic Crystallization and Structural Aspects of Agomelatine Metastable Form X Prepared by Combined Antisolvent/Cooling Process
Original language description
Polymorphism is of great interest to the pharmaceutical industry because polymorphs have different physicochemical properties such as dissolution rate. In the present work, the influence of process conditions on the polymorphic antisolvent crystallization and transformations during cooling crystallization of agomelatine metastable form X from water/methanol solution has been investigated with a view of designing a robust process that includes not only crystallization but also filtration, filter cake washing, and drying. The competitive stability method was used in order to identify regions of the parametric space (water/methanol ratio, process temperature, and initial concentration) in which the crystallization of form X can be feasible. The formation of agomelatine form X was confirmed by subsequent kinetic experiments. The influence of process parameters such as the intensity of agitation, the antisolvent addition rate, and the precipitation temperature on the yield and particle size of the crystalline product was also investigated. The batch antisolvent crystallization of the metastable form X was monitored using in-line Raman spectroscopy and FBRM probe, and the type of the resulting polymorph has been confirmed by X-ray powder diffraction (XRPD). Finally, the effect of the obtained crystals of metastable form X on downstream operations-namely, filtration and drying-has been studied.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-05534S" target="_blank" >GA15-05534S: Structure-property relationships and breakage dynamics of complex granular material</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic Process Research & Development
ISSN
1083-6160
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
33-43
UT code for WoS article
000369880400004
EID of the result in the Scopus database
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